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Significance The analysis of gene expression in peripheral whole blood of US young adults in their late 30s revealed socioeconomic status-based inequalities in the molecular underpinnings of the most common… Click to show full abstract
Significance The analysis of gene expression in peripheral whole blood of US young adults in their late 30s revealed socioeconomic status-based inequalities in the molecular underpinnings of the most common chronic conditions of aging. Associations involved immune, inflammatory, ribosomal, and metabolic pathways, and extra- and intra-cellular signaling. Body mass index was a plausible, sizable mediator of many associations. Results point to new ways of thinking about how social inequalities “get under the skin” and also call for renewed efforts to prevent chronic conditions of aging decades before diagnoses.
Journal Title: Proceedings of the National Academy of Sciences of the United States of America
Year Published: 2022
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