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Significance Brain state fluctuates throughout the course of the day. Whether and how these fluctuations impact signal propagation in the brain remains unknown. Here, we used optogenetic stimulation during different… Click to show full abstract
Significance Brain state fluctuates throughout the course of the day. Whether and how these fluctuations impact signal propagation in the brain remains unknown. Here, we used optogenetic stimulation during different brain states to show that the coupling between neurons modulates the spread of signals across cortical circuits in a state-dependent manner. Our results indicate that brain state influences how far electrical signals travel in neocortex and suggest a revision of computational models relying on robust signal propagation across neural networks.
Journal Title: Proceedings of the National Academy of Sciences of the United States of America
Year Published: 2022
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