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Significance An efficient innate immune response is essential in the host’s immune protection during infection before adaptive immunity intervenes. We show that the earliest neutrophil infiltration to the lymph node… Click to show full abstract
Significance An efficient innate immune response is essential in the host’s immune protection during infection before adaptive immunity intervenes. We show that the earliest neutrophil infiltration to the lymph node via high endothelial venules is facilitated by lymph flow via delivering chemokines (i.e., Chemokine [C-X-C motif] 1/2 [CXCL1/2]) from the site of infection, which is much faster and more efficient than delivering lymphatic trafficking cells. Lymphatic dysfunction during skin inflammation impairs neutrophil migration and bacteria clearance. Our finding demonstrates the significance of lymph flow in innate immune protection and explains how preexisting inflammation conditions, such as dermatitis, can compromise lymph flow and result in higher risk and prolonged infections.
Journal Title: Proceedings of the National Academy of Sciences of the United States of America
Year Published: 2022
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