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Significance Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) levels regulate cell membrane voltage by gluing two halves of a K+ channel together and opening the pore. PI(4)P competes with this process. Because both of… Click to show full abstract
Significance Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) levels regulate cell membrane voltage by gluing two halves of a K+ channel together and opening the pore. PI(4)P competes with this process. Because both of these lipids are relatively abundant in the plasma membrane and are directly interconvertible through the action of specific enzymes, they may function together to regulate channel activity.
Keywords:
function phosphatidylinositol;
structure function;
phosphatidylinositol;
correlation structure;
phosphatidylinositol lipid;
lipid dependent
Journal Title: Proceedings of the National Academy of Sciences of the United States of America
Year Published: 2022
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Journal Title: Proceedings of the National Academy of Sciences of the United States of America
Year Published: 2022
Link to full text (if available)
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recommendations!