Photo from wikipedia
Significance Essential physiological processes such as cell migration and endocytosis require the assembly and catalyzed disassembly of the cytoskeletal branched networks composed of actin filaments and the Arp2/3 complex. We… Click to show full abstract
Significance Essential physiological processes such as cell migration and endocytosis require the assembly and catalyzed disassembly of the cytoskeletal branched networks composed of actin filaments and the Arp2/3 complex. We used single-molecule fluorescence microscopy to directly observe the molecular mechanisms of branch disassembly. The two proteins glial maturation factor (GMF) and cofilin both carry out branch pruning, releasing the Arp2/3 complex and converting the branched network into linear actin filaments. Although GMF and cofilin are evolutionarily related, they work by different pathways that can function independently but also additively in debranching, suggesting that they play collaborative roles in taking apart branched actin networks.
Journal Title: Proceedings of the National Academy of Sciences of the United States of America
Year Published: 2022
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!