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Significance Social amoebae are ideally suited for studying the transition from unicellularity to multicellularity. Interestingly, their genomes contain a large number of polyketide biosynthetic genes. Although many of the corresponding… Click to show full abstract
Significance Social amoebae are ideally suited for studying the transition from unicellularity to multicellularity. Interestingly, their genomes contain a large number of polyketide biosynthetic genes. Although many of the corresponding natural products are speculated to be involved in orchestrating this transition, little is known about either their structures or functions. Here, we isolate and characterize the polyketide synthase–derived polyketide, a deep-yellow pigment, which prevents premature hatching of amoebal spores. This study provides a robust approach to study polyketides in their physiological and ecological context.
Journal Title: Proceedings of the National Academy of Sciences of the United States of America
Year Published: 2022
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