LAUSR

Significance The cortex is particularly vulnerable to perturbations during sensitive periods, such as the critical period when manipulating sensory experience can induce long-lasting changes in brain structure. Depriving rodents of vision in one eye (known as monocular deprivation [MD]) reduces network activity over two days, whereby inhibitory neurons decrease their firing rates one day after MD, while excitatory neurons are delayed by an additional day. We use spiking networks to mechanistically dissect the requirements for this independent firing-rate regulation after sensory deprivation. We find that in networks stabilized by recurrent inhibition, at least two interneuron subtypes (parvalbumin-expressing and somatostatin-expressing interneurons) are necessary to dynamically alter the circuit response after deprivation and generalize the result across sensory cortices.