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Significance Autoimmune demyelination is driven by pathogenic T cells and inflammatory myeloid cells. How myeloid and T cells functionally interact and contribute to inflammatory demyelinating disease, such as multiple sclerosis,… Click to show full abstract
Significance Autoimmune demyelination is driven by pathogenic T cells and inflammatory myeloid cells. How myeloid and T cells functionally interact and contribute to inflammatory demyelinating disease, such as multiple sclerosis, remains incompletely understood. This study identifies a caspase-8–mediated pathway in macrophages that suppresses inflammasome-dependent interleukin-1β production and autoimmunity during inflammatory demyelination. The study provides insights into the interplay between infiltrated myeloid cells and autoreactive T cells in multiple sclerosis that may also have implications for other autoimmune inflammatory diseases.
Journal Title: Proceedings of the National Academy of Sciences of the United States of America
Year Published: 2022
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