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Significance Pluripotency and development can be governed at the level of epigenetics. Growing lines of evidence underscore the importance of the Set1A/complex of proteins associated with SET1 (COMPASS) histone 3… Click to show full abstract
Significance Pluripotency and development can be governed at the level of epigenetics. Growing lines of evidence underscore the importance of the Set1A/complex of proteins associated with SET1 (COMPASS) histone 3 lysine 4 methyltransferase complex in embryogenesis and neurodevelopment. We show that the catalytic SET domain of Set1A is essential for mouse embryogenesis; however, having this domain extends the viability of embryos compared to complete loss of Set1A. We additionally show that Ing5, a core component of several complexes involved in histone acetylation, can functionally interact with Set1AΔSET in regulating ESC viability and developmental gene expression. Insights into their physiological activity and regulation will assist our understanding of their dysfunction in disease and ultimately facilitate the discovery of new targets for future therapy.
Journal Title: Proceedings of the National Academy of Sciences of the United States of America
Year Published: 2022
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