LAUSR

Significance The progressive nature of brain disorders such as multiple sclerosis (MS) reflects an increasing burden of axonal injury and loss induced by neuroinflammation and demyelination. Previously, we found that phloretin, a flavonoid abundantly present in apples and strawberries, reduces neuroinflammation by driving phagocytes toward an antiinflammatory phenotype. In this study, we provide evidence that phloretin enhances remyelination in ex vivo and in vivo animal models by stimulating oligodendrocyte precursor cell maturation. These results offer future perspectives for phloretin as a therapeutic strategy for neurodegenerative disorders such as MS.