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In our study we presented functional and immuno-histochemical evidence for the presence of presynaptic N -methyl-D-aspartate receptors (pre-NMDARs) at parallel fi ber – Purkinje cell (PF-PC) synapses in the adult… Click to show full abstract
In our study we presented functional and immuno-histochemical evidence for the presence of presynaptic N -methyl-D-aspartate receptors (pre-NMDARs) at parallel fi ber – Purkinje cell (PF-PC) synapses in the adult cerebellum. As in young rodents, pre-NMDARs are required to induce PF-PC synaptic plasticity (2). Using cell-speci fi c deletion of NMDARs in granule cells (GCs) or PCs, we demonstrated that only GC NMDARs are robustly involved in PF-PC synaptic plasticity and vesti-buloocular re fl ex (VOR) adaptation. Our data contradict those by Piochon et al. (3),
Journal Title: Proceedings of the National Academy of Sciences of the United States of America
Year Published: 2022
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