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Significance The human zinc finger antiviral protein ZAP potently restricts many important viruses such as SARS-CoV-2 and HIV. ZAP comes in two flavors, with a long and a short variant… Click to show full abstract
Significance The human zinc finger antiviral protein ZAP potently restricts many important viruses such as SARS-CoV-2 and HIV. ZAP comes in two flavors, with a long and a short variant exhibiting slightly different functions that demand characterization. We carefully dissected how these ZAP variants are made, and revealed that the ZAP variants regulate the RNAs of many genes involved in new cellular pathways, including a cellular stress response and a pathway that induces cell migration. Hence, ZAP emerges as a regulator of important cellular processes with relevance to cancer. Our elucidation of the synthesis, cellular targets and pathways of its variants is paramount to pharmacologically target ZAP for immunomodulation or cancer treatment, of which we also provide proof of concept.
Journal Title: Proceedings of the National Academy of Sciences of the United States of America
Year Published: 2022
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