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Significance Community-acquired pneumonia (CAP) is the most common infectious cause of death worldwide. In this work, we present a panel of protease-responsive nanosensors that leverage aberrant host protease activity in… Click to show full abstract
Significance Community-acquired pneumonia (CAP) is the most common infectious cause of death worldwide. In this work, we present a panel of protease-responsive nanosensors that leverage aberrant host protease activity in pneumonia to generate a urinary readout of disease. Notably, the urine signatures of host responses can also be used to differentiate between bacterial and viral pneumonia. These nanosensors constitute a possible route to diagnosing pneumonia that is orthogonal to existing clinical tests, thus opening a direction of study for pneumonia diagnostics.
Journal Title: Proceedings of the National Academy of Sciences of the United States of America
Year Published: 2022
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