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Significance Development of effective cellular therapy strategies against acute myeloid leukemia (AML) remains a major therapeutic challenge. Memory-like natural killer (NK) cells armed with a TCR-like chimeric antigen receptor (CAR)… Click to show full abstract
Significance Development of effective cellular therapy strategies against acute myeloid leukemia (AML) remains a major therapeutic challenge. Memory-like natural killer (NK) cells armed with a TCR-like chimeric antigen receptor (CAR) targeting a unique neoepitope presented by HLA-A2 exhibit potent activity against nucleophosphmin-1 (NPM1)-mutated AML in vitro and in vivo. Multiomics analyses provide insight into the key pathway genes upregulated upon CAR engineering and target engagement in cytokine-induced memory-like (CIML) NK cells.
Journal Title: Proceedings of the National Academy of Sciences of the United States of America
Year Published: 2022
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