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Significance Arsenic is a centuries-old, naturally occurring toxicant, and its cellular effect is still poorly understood. The significance of this work is three-fold. First, among a battery of oxidizing and… Click to show full abstract
Significance Arsenic is a centuries-old, naturally occurring toxicant, and its cellular effect is still poorly understood. The significance of this work is three-fold. First, among a battery of oxidizing and alkylating agents, arsenite exposure caused a unique reprogramming of wobble queuosine in the transfer RNA (tRNA) epitranscriptome, which depended upon the micronutrient precursor queuine and was linked to codon-biased shifts in the translation of metabolic proteins known to be linked to arsenite toxicity. Second, we showed that the tRNA epitranscriptome is dynamically and differentially regulated by exposure to a variety of toxicants. Finally, the results have implications for the role of queuine as a micronutrient that determines the human cell response to toxic stresses.
Journal Title: Proceedings of the National Academy of Sciences of the United States of America
Year Published: 2022
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