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Significance A major challenge in reproductive sciences today is to decipher the molecular basis of cell–cell communication during early pregnancy. The present study reveals that extracellular vesicles (EVs) generated by… Click to show full abstract
Significance A major challenge in reproductive sciences today is to decipher the molecular basis of cell–cell communication during early pregnancy. The present study reveals that extracellular vesicles (EVs) generated by human endometrial stromal cells carry a variety of molecular cargo that augments decidualization, stimulates angiogenesis, and modulates trophoblast differentiation. We also show that the pleiotropic functions of EVs support communication between various cell types within the uterus that is vital in promoting decidualization, angiogenesis, and trophoblast development.
Journal Title: Proceedings of the National Academy of Sciences of the United States of America
Year Published: 2022
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