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Significance Reactive oxygen/nitrogen species (ROS/RNS) were long considered unwanted byproducts that cells have to neutralize. However, the field of redox biology discovered that ROS/RNS are often produced by intent and… Click to show full abstract
Significance Reactive oxygen/nitrogen species (ROS/RNS) were long considered unwanted byproducts that cells have to neutralize. However, the field of redox biology discovered that ROS/RNS are often produced by intent and used as signaling molecules. Recently, novel technologies such as gas plasma have aimed at generating vast levels of ROS for therapeutic purposes. One of these purposes is loading liquids with ROS to target cancer that has spread in the abdomen. Here, we unraveled the mechanism of these liquids as hydrogen peroxide. This finding is dramatic as it allows transferring findings from plasma technology to redox biology. Moreover, low-dose hydrogen peroxide is easy to produce and is known in clinics. Our findings may open a chapter of redox intervention in cancer management.
Journal Title: Proceedings of the National Academy of Sciences of the United States of America
Year Published: 2022
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