LAUSR

Significance Most cells in the human body reside in a dormant state characterized by slow growth and minimal motility. During episodes such as wound healing, stem cell activation, and cancer growth, cells adapt to a more dynamic behavior characterized by proliferation and migration. However, little is known about the mechanical forces controlling the transition from static to motile following exit from dormancy. We demonstrate that keratinocyte monolayers install a mechanical system during dormancy that produces a coordinated burst of intercellular mechanical tension only minutes after dormancy exit. The activated forces are essential for large-scale displacements of otherwise motility-restricted cell sheets. Thus, cells sustain a mechanical system during dormancy that idles in anticipation of cell cycle entry and prompt activation of motion.