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Significance • Phospholipase A2 receptor (PLA2R) is the major autoantigen responsible for causing the rare autoimmune kidney disease, membranous nephropathy (MN).• PLA2R autoantibodies primarily bind to a dominant epitope located… Click to show full abstract
Significance • Phospholipase A2 receptor (PLA2R) is the major autoantigen responsible for causing the rare autoimmune kidney disease, membranous nephropathy (MN).• PLA2R autoantibodies primarily bind to a dominant epitope located within a 28-amino acid peptide in the cysteine-rich domain of PLA2R.• We generated a minimal peptide necessary for binding autoantibodies with high affinity for developing future therapies.• We report the high-resolution structure of PLA2R with its domain orientation and define key regions within the domain epitope critical for its immunogenicity in MN.
Journal Title: Proceedings of the National Academy of Sciences of the United States of America
Year Published: 2022
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