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Significance Neurofibromatosis type 2 (NF2) is caused by slow-growing benign schwannomas that develop throughout the body and cause severe pain, morbidity, and mortality. Surgical resection and radiotherapy are the standards… Click to show full abstract
Significance Neurofibromatosis type 2 (NF2) is caused by slow-growing benign schwannomas that develop throughout the body and cause severe pain, morbidity, and mortality. Surgical resection and radiotherapy are the standards of care for NF2 but have major limitations. The paucity of NF2 therapeutic options is a major unmet medical need. Here, we show that bacteriotherapy immunotherapy using an attenuated strain of Salmonella typhimurium can control this neoplasm in a preclinical mouse model. This strategy decreased angiogenesis and the volume of the injected tumor and induced a systemic immune response as well as an immunological memory response that targeted distal tumors and prevented development of new lesions. These results support the evaluation of attenuated S. typhimurium as a treatment for NF2 disease.
Journal Title: Proceedings of the National Academy of Sciences of the United States of America
Year Published: 2022
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