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Significance Proper placental development is critical for pregnancy success. Placental maldevelopment is linked with serious pregnancy complications that jeopardize the health of both mother and child. The parenchymal cells of… Click to show full abstract
Significance Proper placental development is critical for pregnancy success. Placental maldevelopment is linked with serious pregnancy complications that jeopardize the health of both mother and child. The parenchymal cells of the placenta are trophoblasts, which arise from trophoblast stem cells differentiating through one of two distinct lineage pathways: syncytiotrophoblast, which regulates maternal-fetal nutrient transfer, and extravillous trophoblasts (EVTs), which remodel the uterine vasculature. Glial cells missing-1 (GCM1) is a transcription factor classically associated with syncytiotrophoblast formation, but GCM1 is also expressed in EVTs. In this study, human trophoblast stem cells were used to corroborate the role of GCM1 in syncytiotrophoblast formation and uncover its critical role in EVT development. We conclude that GCM1 contributes to multiple aspects of human placentation.
Journal Title: Proceedings of the National Academy of Sciences of the United States of America
Year Published: 2022
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