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Significance Interaction between peptide–major histocompatibility complexes (pMHCs) and T cell receptors (TCRs) is the key mediator for tumor cell recognition by cytotoxic T cells. We performed a multimodal analysis on… Click to show full abstract
Significance Interaction between peptide–major histocompatibility complexes (pMHCs) and T cell receptors (TCRs) is the key mediator for tumor cell recognition by cytotoxic T cells. We performed a multimodal analysis on a prostate tissue antigen, PAP, to reveal peptides restricted by MHC I. Cognate TCRs were then isolated against those candidate targets. Information regarding both the epitopes and TCRs can be beneficial in designing new treatments for prostate cancer. Our platform can also be generalizable to other cancer antigens and different HLA types.
Journal Title: Proceedings of the National Academy of Sciences of the United States of America
Year Published: 2022
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