LAUSR

Significance Elucidation of the pathology triggered by SARS-CoV-2 infection is essential to control the pandemic. We found that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) accumulates in the pulmonary vessels, causing exudative vasculitis accompanied by the emergence of noncanonical monocytes that specifically produce a platelet activating factor, thrombospondin-1, and the formation of myosin light chain 9 (Myl9)–containing microthrombi in the lungs of coronavirus disease 2019 (COVID-19) patients with fatal disease. More interestingly, we demonstrate that SARS-CoV-2–induced platelet activation causes an increase in the plasma Myl9 level, which is closely correlated with clinical severity. The measurement of plasma Myl9 with other markers allowed us to diagnose the severity of the disease more accurately, which is crucial for providing appropriate medical care for COVID-19 patients.