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Significance Transport patterns of mitochondria are diverse with changes in velocity, directions, and pauses. Previous studies have mainly aimed at unraveling how motor proteins and their calcium dependency direct transport… Click to show full abstract
Significance Transport patterns of mitochondria are diverse with changes in velocity, directions, and pauses. Previous studies have mainly aimed at unraveling how motor proteins and their calcium dependency direct transport but fall short to elucidate all transport patterns. Here, we report that tubulin conformation, highly dependent on guanosine triphosphate (GTP) hydrolysis, regulates mitochondrial transport. On the one hand, guanosine diphosphate (GDP)- or GTP-bound tubulin alters the straightness of the microtubule bundles, influencing transport especially when cargo is positioned within the microtubule bundle. On the other hand, the GTP-bound conformation facilitates kinesin-driven transport at the rim of the microtubule bundle. Microtubules are therefore not merely a passive player for mitochondrial transport as tubulin can directly regulate mitochondrial transport.
Journal Title: Proceedings of the National Academy of Sciences of the United States of America
Year Published: 2022
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