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Significance Circadian clocks adapt us to our rhythmic world, setting the tempo to our lives. Their disruption (e.g., by shiftwork) therefore carries a severe cost in health. The suprachiasmatic nucleus… Click to show full abstract
Significance Circadian clocks adapt us to our rhythmic world, setting the tempo to our lives. Their disruption (e.g., by shiftwork) therefore carries a severe cost in health. The suprachiasmatic nucleus (SCN) is the principal brain clock of mammals, its time keeping pivoting around a delayed negative feedback loop of gene and protein expression. By using “translational switching” as a means to reversibly control the expression of the negative feedback regulator Cryptochrome 1 (CRY1) in SCN organotypic slices, we show that acute changes in the level of CRY1 define circadian time. We thereby bridge theoretical and biochemical perspectives of the SCN clockwork.
Journal Title: Proceedings of the National Academy of Sciences of the United States of America
Year Published: 2022
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