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Significance The plant hormone auxin (indole-3-acetic acid [IAA]) plays a central role in regulating plant growth and development, but the regulation of IAA biosynthesis is poorly understood. Here, we identified… Click to show full abstract
Significance The plant hormone auxin (indole-3-acetic acid [IAA]) plays a central role in regulating plant growth and development, but the regulation of IAA biosynthesis is poorly understood. Here, we identified a key push and pull feedback mechanism, which governs auxin biosynthesis through the tryptophan aminotransferase TAA1. We demonstrate that novel inhibitors of TAA1 function in both monocots and eudicots and present a catalytic mechanism that explains both its substrate specificity and its inhibition.
Journal Title: Proceedings of the National Academy of Sciences of the United States of America
Year Published: 2022
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