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Significance Selenium-binding protein 1 (SELENBP1) is up-regulated in the prefrontal cortex of patients with schizophrenia as per postmortem reports, including the present study. However, no causative link between SELENBP1 and… Click to show full abstract
Significance Selenium-binding protein 1 (SELENBP1) is up-regulated in the prefrontal cortex of patients with schizophrenia as per postmortem reports, including the present study. However, no causative link between SELENBP1 and schizophrenia has yet been established. Here, we examined the anatomical deformities, physiological properties, electroencephalographic characteristics of the frontal cortex, and behaviors of animal models overexpressing human SELENBP1 to prove the role of SELENBP1 in schizophrenia pathogenesis. The animals exhibited several anatomical and electroencephalographic features of schizophrenia in the frontal cortex. Importantly, they showed behavioral endophenotypes related to the negative symptoms of schizophrenia as well as reduced sociability. These findings provide a causative link between PFC SELENBP1 upregulation and negative symptoms of schizophrenia.
Journal Title: Proceedings of the National Academy of Sciences of the United States of America
Year Published: 2022
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