LAUSR

Significance Pavlovian threat learning is a primary translational model for understanding the brain systems that underlie anxiety and trauma-related psychopathology. The amygdala has traditionally played a central role in this important form of learning across species. However, recent human neuroimaging work has revealed inconsistent findings regarding the role of human amygdala in threat and safety learning. To address this discrepancy, we examined amygdala responses to threat-predictive cues in a large sample of human participants. We found robust evidence for amygdala responses during threat conditioning and, further, that these responses occurred in a temporally and anatomically specific manner. Our results reveal clear evidence of human amygdala involvement in associative learning and offer insight into why some neuroimaging work has yielded equivocal findings.