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Significance The presence of dsRNA in the cytosol is a marker of infection and elicits an immune response. One aspect of this immune response is the activation of the eIF2α… Click to show full abstract
Significance The presence of dsRNA in the cytosol is a marker of infection and elicits an immune response. One aspect of this immune response is the activation of the eIF2α kinase PKR, which results in translational reprogramming and stress granule formation. Here, we show that dsRNA induces the formation of a novel condensate by PKR that is distinct from other known ribonucleoprotein assemblies. These results challenge prior observations that PKR is recruited to stress granules and suggest that the condensation of PKR may be a mechanism that cells use to modulate PKR activation.
Journal Title: Proceedings of the National Academy of Sciences of the United States of America
Year Published: 2022
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