Photo from wikipedia
Significance Segregation of the replicated single unit mitochondrial genome of Trypanosoma brucei requires a large hardwired structure that connects the organellar DNA with the flagellar basal body. The cytosolic part… Click to show full abstract
Significance Segregation of the replicated single unit mitochondrial genome of Trypanosoma brucei requires a large hardwired structure that connects the organellar DNA with the flagellar basal body. The cytosolic part of this structure consists of filaments made of p197 molecules, a protein with a molecular weight of approximately 660 kDa. The N terminus of p197 is anchored to the peripheral mitochondrial outer membrane protein TAC65, whereas its C terminus connects to the base of the basal body. The large α-helical central domain of p197 consists of approximately 26 repeats each 175 aa in length. It provides a flexible spacer that connects the outer membrane with the basal body and determines the distance between the two structures.
Journal Title: Proceedings of the National Academy of Sciences of the United States of America
Year Published: 2022
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!