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Significance Many noncoding RNA molecules are indispensable components of macromolecular complexes that govern critical cellular processes. Telomerase RNA is a long noncoding RNA essential for maintaining chromosome stability and cellular… Click to show full abstract
Significance Many noncoding RNA molecules are indispensable components of macromolecular complexes that govern critical cellular processes. Telomerase RNA is a long noncoding RNA essential for maintaining chromosome stability and cellular immortality in eukaryotes. In this study, we discover a basidiomycete fungal telomerase RNA that is processed from a messenger RNA (mRNA) transcript that encodes a conserved protein. Our finding demonstrates an unprecedented biogenesis pathway for generating a functional long noncoding RNA from a protein-coding mRNA precursor.
Journal Title: Proceedings of the National Academy of Sciences of the United States of America
Year Published: 2022
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