LAUSR

Significance Current treatment options for Brain Metastases (BM) still result in reduced survival outcomes in affected patients, emphasizing the need for a better understanding of the disease and consequently more efficient therapies. In this study, we shed light on the molecular profile of brain metastatic cells during the early stages of the BM cascade and show that targeting certain gene(s) commonly up-regulated in these cells irrespective of their primary tumor of origin is capable of impeding the establishment of BM. Our findings uncover unique factors involved in BM and could lead to the development of more effective and preventive therapeutic options against BM.