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Significance Here, we show that transcription factor EB (TFEB), thought to be a key regulator of autophagy and lysosome function, can be regulated by T regulatory (Treg)-related cues in a… Click to show full abstract
Significance Here, we show that transcription factor EB (TFEB), thought to be a key regulator of autophagy and lysosome function, can be regulated by T regulatory (Treg)-related cues in a mechanistic target of rapamycin complex 1-independent manner and is crucial for Treg cell generation and function. TFEB deficiency affects Treg mitochondrial fitness and could result in impaired generation and function of Treg cells in autoimmune disease and tumors irrespective of autophagy and lysosome activity. These data demonstrate that TFEB acts as a critical regulator for orchestrating Treg generation and function in response to local environmental cues.
Journal Title: Proceedings of the National Academy of Sciences of the United States of America
Year Published: 2022
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