LAUSR

Significance Leveraging intracranial recordings from patients with Parkinson’s disease and essential tremor, the applied analyses allowed for derivation of relationships between neural signals across spatiotemporal resolutions, techniques that may facilitate interpretation of aggregate-level oscillations in various neuroscientific contexts from the perspective of the single-neuron resolution. Of relevance in Parkinson’s disease, the applied methodologies allowed us to establish a link between single-neuron bursting and elevated local field potential (LFP) activities, reconciling parallel theories of neurocircuit dysfunction. Directional connectivity analyses between single-neuron and LFP signals furthermore allowed us to speculate on the origin of beta and tremor-related oscillations associated with Parkinson’s disease and essential tremor, respectively. Ultimately, our findings may aid in developing targeted neurotherapeutics to address aberrant pattens of neural activity.