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Significance This article reports an exciting breakthrough in the translation of the biomimicking hyperboloidal structure into three-dimensional tissue-engineered bone grafts and reveals how the nature-derived hyperboloid structure affects osteogenesis and… Click to show full abstract
Significance This article reports an exciting breakthrough in the translation of the biomimicking hyperboloidal structure into three-dimensional tissue-engineered bone grafts and reveals how the nature-derived hyperboloid structure affects osteogenesis and angiogenesis for expedited bone regeneration. We fabricated triply periodic minimal surfaces (TPMSs) embodied with hyperboloidal topography with different Gaussian curvatures. The wavy TPMS scaffolds directed the osteogenic differentiation and angiogenic paracrine of mesenchymal stem cells through the hyperboloidal topography-induced cytoskeleton reorganization and nuclear deformation, accelerating bone regeneration. We believe that these features can grant our scaffolds application as simple, safe, efficient, and personalized bone grafts with notable clinical translation potential.
Journal Title: Proceedings of the National Academy of Sciences of the United States of America
Year Published: 2022
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