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Significance Arp2/3 complex is a protein assembly with seven subunits that forms actin filament branches on the sides of preexisting “mother” actin filaments. This process generates growing actin filaments for… Click to show full abstract
Significance Arp2/3 complex is a protein assembly with seven subunits that forms actin filament branches on the sides of preexisting “mother” actin filaments. This process generates growing actin filaments for cellular locomotion and intracellular movements. Binding proteins called nucleation-promoting factors and to the side of a mother filament, activates intrinsically inactive Arp2/3 complex to initiate a daughter filament. We determined the structure of the branch junction with active Arp2/3 complex at 3.5 Å resolution by cryo-electron microscopy. Activation involves rotation of two blocks of structure to position the actin-related proteins Arp2 and Arp3 next to form the base for the actin filament branch and to allow interactions with five actin subunits in the mother filament.
Journal Title: Proceedings of the National Academy of Sciences of the United States of America
Year Published: 2022
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