LAUSR

Significance In a human cell, transcription of a particular gene invariably fluctuates with time, and the fluctuations of several transcripts can be correlated because they are regulated by the same transcription factor. By developing a single-cell transcriptome method with high detectability (MALBAC-DT) to measure pair-wise correlation among mRNA abundance under steady-state conditions, we discovered correlated gene modules (CGMs), a group of genes whose expression are synchronized in order for them to work together to carry out certain biological functions, such as protein synthesis or cholesterol synthesis. CGMs provide information regarding genome’s biological functions through protein-to-protein interactions.