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Significance Understanding the mechanisms of spatial heterogeneity in tuberculosis (TB) transmission may enhance the effectiveness of spatially targeted interventions. In this work, we integrated whole-genome sequences of 2,712 Mycobacterial tuberculosis… Click to show full abstract
Significance Understanding the mechanisms of spatial heterogeneity in tuberculosis (TB) transmission may enhance the effectiveness of spatially targeted interventions. In this work, we integrated whole-genome sequences of 2,712 Mycobacterial tuberculosis isolates and geographic coordinates of the patients’ residences in a large urban catchment area in Lima, Peru, to clarify if local transmission is the primary driver of high rates of TB disease in spatially distinct areas. We find that spatially specific TB incidence does not correlate closely to the frequency of local transmission. This suggests that understanding the causes that lead to spatially distinct TB hotspots is necessary for spatially targeting interventions.
Journal Title: Proceedings of the National Academy of Sciences of the United States of America
Year Published: 2022
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