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Significance The fields of immunology and neuroscience have evolved in isolation, partially justified by the view that the brain–blood barrier is impermeable, however, the newly developing science of aging has… Click to show full abstract
Significance The fields of immunology and neuroscience have evolved in isolation, partially justified by the view that the brain–blood barrier is impermeable, however, the newly developing science of aging has revealed that chronic, high levels of proinflammatory immune factors accelerate the aging process in the brain. MRI scans identify a decline in cortical volume as a marker for aging. We extracted a cytokine clock (CyClo) that was able to estimate physiological age based on the concentrations of a set of blood proteins that change throughout life. Canonical correlation analysis reveals that the variability in the volume of different functional cortical networks associates differentially with age, sex, and CyClo, suggesting selective vulnerabilities of certain functional networks to circulating levels of immune markers of aging.
Journal Title: Proceedings of the National Academy of Sciences of the United States of America
Year Published: 2022
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