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Significance It has long been claimed that the young brain is capable of recovery and reorganization that does not occur in adults. However, evidence has been mixed, and the principles… Click to show full abstract
Significance It has long been claimed that the young brain is capable of recovery and reorganization that does not occur in adults. However, evidence has been mixed, and the principles and constraints of developmental plasticity are not well understood. Here, we study long-term language outcomes in adolescents and young adults who suffered a major stroke at birth to the classic left-hemisphere (LH) language areas. Our participants have developed normal sentence processing abilities in right-hemisphere (RH) areas homotopic to typical LH regions, near the RH regions responsible for processing vocal emotion. There is indeed a dramatic capacity for early brain reorganization. However, the systematic pattern of reorganization across individuals suggests that only certain brain areas are capable of taking on language functions.
Journal Title: Proceedings of the National Academy of Sciences of the United States of America
Year Published: 2022
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