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Significance Humans have adapted to diverse environments, but few studies have linked regions of the genome with evidence of selection to phenotypes. We generated an integrative dataset of genomic, transcriptomic,… Click to show full abstract
Significance Humans have adapted to diverse environments, but few studies have linked regions of the genome with evidence of selection to phenotypes. We generated an integrative dataset of genomic, transcriptomic, and biomarker data for the Tsimane and the Moseten—two indigenous Amerindian populations in Bolivia. From analyses focused on Tsimane individuals, we found evidence for adaptation at genes and traits involved in immunity, which makes sense given that infection has strong effects on physiology and fitness in this population. Using phenotypic data from both populations, we were able to link genotypes to the immune and metabolic traits that are potentially advantageous. This study expands our knowledge of natural selection in Amerindians and uncovers previously undescribed loci of evolutionary and biomedical relevance.
Journal Title: Proceedings of the National Academy of Sciences of the United States of America
Year Published: 2022
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