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Significance Repetitive stereotyped behavior is a common symptom in various psychiatric disorders, such as obsessive–compulsive disorder (OCD). The midbrain dopaminergic system has been implicated in this phenotype, but the precise… Click to show full abstract
Significance Repetitive stereotyped behavior is a common symptom in various psychiatric disorders, such as obsessive–compulsive disorder (OCD). The midbrain dopaminergic system has been implicated in this phenotype, but the precise location and circuit mechanism whereby it takes its action are unknown. Here, using an OCD animal model, we reveal that dopamine neurons in substantia nigra pars compacta (SNc) control the repetitive behavior via a dual gating mechanism from striatal and cortical projections. Our results suggest potential new targets in both pharmacological and brain-stimulation treatments for OCD.
Journal Title: Proceedings of the National Academy of Sciences of the United States of America
Year Published: 2022
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