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Significance Exosomes are a type of membranous extracellular vesicle and have been highlighted for their various roles in the transmission of microorganisms. Exportins are frequently found in exosomes. However, the… Click to show full abstract
Significance Exosomes are a type of membranous extracellular vesicle and have been highlighted for their various roles in the transmission of microorganisms. Exportins are frequently found in exosomes. However, the function of exportins sorted in exosomes remains unknown. Here, we isolated exosomes from saliva of approximately 30,000 small brown planthoppers, which are vectors of rice stripe virus (RSV). We found that a fragmented exportin 6 acted as a vehicle for transporting RSV into exosomes to overcome the barrier of insect salivary glands for horizontal transmission. Interference with the expression of exportin 6 remarkably reduced viral transmission to rice plants. Therefore, exportin 6 would represent an ideal target for controlling the outbreak of insect-borne viruses.
Journal Title: Proceedings of the National Academy of Sciences of the United States of America
Year Published: 2022
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