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Significance Protein degradation is an important regulation mechanism in biology. Although HetF has long been predicted to be a putative protease in the filamentous cyanobacterium Anabaena sp. PCC 7120, its… Click to show full abstract
Significance Protein degradation is an important regulation mechanism in biology. Although HetF has long been predicted to be a putative protease in the filamentous cyanobacterium Anabaena sp. PCC 7120, its activity or substrate has never been demonstrated. In this study, we provided in vitro and in vivo evidence for the protease activity of HetF acting on PatU3 as a specific substrate. The degradation of PatU3 by HetF relieves the inhibitory effects of PatU3 on cell division and heterocyst development, thus providing a mechanism for the coordination of the two biological processes. The proteolytic system reported here enriched our understanding on the control mechanism for cell division and development in cyanobacteria.
Journal Title: Proceedings of the National Academy of Sciences of the United States of America
Year Published: 2022
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