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Significance The human endometrium represents one of the most-regenerative tissues, known for its ability to undergo cyclic breakdown and scarless repair in a few days. Endometrial organoids have provided unprecedented… Click to show full abstract
Significance The human endometrium represents one of the most-regenerative tissues, known for its ability to undergo cyclic breakdown and scarless repair in a few days. Endometrial organoids have provided unprecedented insights into human endometrial biology, functions, and diseases. However, the broader application of organoids in basic and clinical research is hampered by the use of an ill-defined mixture of extracellular matrix proteins and growth factors derived from mouse cancer cells. We have developed endometrial extracellular matrix-based hydrogels. Human organoids developed in these hydrogels are biochemically similar to the native tissue from which they are derived. Our endometrial hydrogels overcome a major limitation of current organoid technology and would support the development of more physiologically and translationally relevant endometrial organoid models.
Journal Title: Proceedings of the National Academy of Sciences of the United States of America
Year Published: 2022
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