Photo by cdc from unsplash
Significance Among vectors, ticks transmit the most diverse human and animal pathogens, leading to an increasing number of new challenges worldwide. In this study, we found that Ltbr knockout mice… Click to show full abstract
Significance Among vectors, ticks transmit the most diverse human and animal pathogens, leading to an increasing number of new challenges worldwide. In this study, we found that Ltbr knockout mice were more susceptible to Lyme disease spirochetes and showed that a 15-kDa protein (Ixodes persulcatus salivary protein [IpSAP]) functioned as an immunosuppressant to facilitate the transmission and infection of Lyme spirochetes. IpSAP immunization provided mice with significant protection against I. persulcatus–mediated Borrelia garinii infection and considerable cross-protection. The significance of this study is to provide potential protein candidates for broad-spectrum vaccine development for the control and prevention of Lyme disease.
Journal Title: Proceedings of the National Academy of Sciences of the United States of America
Year Published: 2022
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!