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Significance More than 20 years have passed since the first total synthesis of eribulin was reported, and numerous attempts thereafter failed to reach the final target; a unified strategy for… Click to show full abstract
Significance More than 20 years have passed since the first total synthesis of eribulin was reported, and numerous attempts thereafter failed to reach the final target; a unified strategy for the total syntheses of eribulin and its macrolactam analogue is reported. These syntheses feature a reverse approach for the construction of cyclic ether structural motifs and an alkyl iodide–aldehyde macrocyclization.
Keywords:
total syntheses;
syntheses eribulin;
unified strategy;
macrolactam analogue;
eribulin macrolactam;
strategy total
Journal Title: Proceedings of the National Academy of Sciences of the United States of America
Year Published: 2022
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Journal Title: Proceedings of the National Academy of Sciences of the United States of America
Year Published: 2022
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!