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Significance Allelic variation in HHIP confers risk of smoking-related lung disease. We show that HHIP is expressed in the medial habenula, where it regulates the motivational properties of nicotine. These… Click to show full abstract
Significance Allelic variation in HHIP confers risk of smoking-related lung disease. We show that HHIP is expressed in the medial habenula, where it regulates the motivational properties of nicotine. These findings have relevance for understanding habenular involvement in nicotine aversion and mechanisms of genetic vulnerability to smoking-related diseases.
Keywords:
habenula regulate;
protein acts;
interacting protein;
acts habenula;
regulate nicotine;
hedgehog interacting
Journal Title: Proceedings of the National Academy of Sciences of the United States of America
Year Published: 2022
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Journal Title: Proceedings of the National Academy of Sciences of the United States of America
Year Published: 2022
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!