Photo from wikipedia
Significance Thyroid hormone (TH) signaling is important for gene regulation and plays an essential role in brain development. However, it remains unknown how TH signaling affects neuronal functions in adulthood.… Click to show full abstract
Significance Thyroid hormone (TH) signaling is important for gene regulation and plays an essential role in brain development. However, it remains unknown how TH signaling affects neuronal functions in adulthood. Using a transgenic mouse (Mf-1) lacking TH signaling only in cerebellar Purkinje cells, we found motor defects and altered long-term synaptic plasticity at parallel fiber–Purkinje cell (PC) synapses in adult Mf-1 mice. Long-term depression was switched to long-term potentiation. This is caused by reduced calcium signals in adult Mf-1 PCs, because genes related to internal calcium release machinery are down-regulated. These phenotypes are not ascribed to adult-onset deficiency of TH signaling in PCs. Our results suggest that TH signaling in neurons during development has decisive effects on neuronal functions in adulthood.
Journal Title: Proceedings of the National Academy of Sciences of the United States of America
Year Published: 2022
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!