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Significance By using the H2O2 sensor (termed as HyPerion), we unravel a unique redox metabolic preference in maintaining the reactive oxygen species (ROS) level of acute myeloid leukemia (AML) cells.… Click to show full abstract
Significance By using the H2O2 sensor (termed as HyPerion), we unravel a unique redox metabolic preference in maintaining the reactive oxygen species (ROS) level of acute myeloid leukemia (AML) cells. HyPerion-low AML cells have enhanced leukemogenic capacities, are enriched for functional leukemia-initiating cells, tend to localize in the endosteal niche, and are more resistant to chemotherapy, which may be fine-tuned by malic enzyme ME1/3. Targeting ME1/3 can efficiently delay the AML development and overcome the drug resistance.
Journal Title: Proceedings of the National Academy of Sciences of the United States of America
Year Published: 2023
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